Vitamin U protects against oxidative damage caused by medicines



Most drugs we take for medical conditions have side effects. Scientists try to design drugs to react with a target as specifically as possible, and not react with other molecules in the body. This is one of the reasons newly-designed drugs go through clinical trials before they can be prescribed by doctors. However, no drug is perfect. Drugs are very reactive chemicals that often react off-target and can cause side-effects. Some side-effects are tolerable because we might be taking the drugs for a short time or the symptoms are mild. However, plenty of drugs are taken for many years for chronic conditions. Other drugs are actually fairly toxic, but are prescribed for emergency situations as a last resort to save someone's life.  

In recent years, scientists in Turkey (Yanardag and Turkyilmaz) have performed a series of studies showing that Vitamin U can have a prophylactic effect when taken before drug administration. Vitamin U prevented oxidative damage caused by amiodarone (https://acsijournal.eu/index.php/ACSi/article/view/7899/3654), pentylenetetrazole (https://pubmed.ncbi.nlm.nih.gov/35833322/), D-galactosamine (https://pubmed.ncbi.nlm.nih.gov/35673974/)(https://pubmed.ncbi.nlm.nih.gov/35670011/), and valproic acid https://pubmed.ncbi.nlm.nih.gov/25802006/.

Vitamin U is a nutrient found in vegetables and fruit, especially cruciferous and stalky vegetables. It is assimilated into the body via the action of the enzyme BHMT-2 and promotes the regeneration of glutathione, the stores of which are rapidly degenerated by taking reactive drugs such as amiodarone. 

Taking Vitamin U supplements to reduce the side effects of specific drug treatments has not been broadly tested in humans and is not FDA approved, so these findings should not be taken as medical advice. However, this research shows that drugs do cause damage that can lead to long term harm, and that simple, naturally-occurring compounds such as Vitamin U can prevent these side effects.