Showing posts with label NAC. Show all posts
Showing posts with label NAC. Show all posts

Longevity and Vitamin U

We age and die as a result of our body accumulating oxidative damage. For example, smoking creates oxygen radicals that damage lung cells. This damage reduces the function of these cells and when enough cells have been damaged or die, lung tissue fails to function and we die from lung failure. 

The best way to live your healthiest life is to reduce future oxidative damage as much as possible. The key to doing this is to restore and maintain high glutathione levels. Glutathione is the main antioxidant in your body that quenches the radicals that damage cells. 

Healthy glutathione levels have been associated with longevity. Studies have shown that centenarians have similar glutathione levels to that of young people. In contrast, people who die at a younger age almost always have a low level of glutathione, which almost certainly contributes to the degenerate condition. 

Can glutathione levels be restored? Evidence suggests they can. Studies on middle age people showed that taking supplements restored their glutathione levels to that of their younger counterparts in 24 weeks.  Studies on mice taking similar supplements found those who received supplements lived 24% longer than those who didn't. Furthermore, biochemical markers of good health improved with supplementation suggesting restoring these biochemical markers is probably a useful predictor of lifespan. 

Does this mean humans taking supplements that restore glutathione levels will live longer lives? As humans aren't mice, we can't extrapolate this data to human longevity, but the results so far are promising.

What's the best way to restore glutathione levels? Glutathione is made up of cysteine, glycine and glutamic acid. In these studies, NAC and glycine are the two amino acids that improved health and longevity in mice and improved health biochemical markers in people (roughly 7 g per day in people). Note that NAC and glycine levels were low in these middle aged people whereas glutamic acid levels were normal, and that NAC is converted into cysteine before becoming a component of glutathione.

Can Vitamin U be substituted for NAC? Quite possibly, although this has not been tested directly. Vitamin U is an amino acid (S-methylmethionine) that is produced naturally by all flowering plants and is found in all produce, especially stalky and cruciferous vegetables. Vitamin U is integrated into the human body by specific enzymes in the liver and kidney. One advantage of taking Vitamin U over NAC is that these enzymes in the liver and kidney specifically regulate the integration of Vitamin U, converting it into cysteine-->glutathione when needed without any of the potential side effects of NAC dosing.

Note that while restoring glutathione levels will minimize further damage from oxidative stress, it won't directly reverse existing damage. However, restoring healthy glutathione levels will allow your body's natural repair systems to heal your body the best they can. 

Vitamin U - A possible natural alternative to N-acetylcysteine (NAC)

The current coronavirus pandemic has changed our lives forever. One of the hallmarks of coronavirus (COVID-19) infection is acute oxidative stress, and as a consequence, life-threatening damage to the endothelial cells lining our blood vessels. It has been proposed that to counter this oxidative stress one may take N-acetylcysteine (NAC) as part of an array of treatment options that may allay this frightening illness.

Dr Roger Seheult 

Dr Chris Martenson 

N-acetylcysteine (NAC) is a popular supplement invented in the 1960s used primarily to optimize glutathione levels. It is normally used in hospitals in emergency situations to treat overdoses of acetaminophen (e.g. Tylenol), which results in an acute and deadly shortage of glutathione in the liver. When acetaminophen is taken as directed, it is safely metabolized by the liver enzymatically. A small amount is oxidized to form N-acetyl-p-benzoquinone imine (NAPQI), which is highly toxic. NAPQI is detoxified in the liver by conjugation with glutathione. However, in overdoses of acetaminophen, NAPQI levels rise dramatically as the regular detoxification processes are overwhelmed. The liver literally cannot regenerate glutathione fast enough to quench the toxic NAPQI. Extensive liver damage and death often ensues. NAC helps by being quickly converted into cysteine, which enables the production of fresh glutathione.

NAC is also sold as a dietary supplement as a means of optimizing glutathione levels on an everyday basis. Glutathione is the master antioxidant in the human body, responsible for detoxifying compounds in the liver as well as reacting with reactive oxygen species that are harmful in large amounts. Glutathione differs significantly to other antioxidants (such as Vitamin C) in that it is made by humans. Our body makes glutathione from three amino acids - glutamate, cysteine and glycine. Levels can get low when our diet is short of these amino acids. The rate-limiting amino acid is usually cysteine, which the body can obtain from the diet following the digestion of protein, and also enzymatically from methionine. When cysteine levels in the diet are inadequate, glutathione levels in the body become inadequate, resulting in general inflammation. Most chronic illnesses are characterized as having low glutathione levels and restoring glutathione levels may help reduce inflammation, if not actually reverse the underlying problem. 

Vitamin U (S-methylmethionine) is a naturally abundant nutrient found in vegetables and fruits, especially cruciferous (e.g. cabbage, kale) and stalky vegetables (e.g. celery, asparagus). Like NAC, one of the functions of Vitamin U is to facilitate glutathione biosynthesis via its conversion to cysteine. Its use as an alternative to NAC in the treatment of acetaminophen overdose has been proposed and remains under investigation. One of the advantages of Vitamin U is that unlike NAC, Vitamin U is already found in many of the foods available in the fresh market, and is therefore unlikely to cause side effects. 

While Vitamin U should not be used in an emergency situation as its efficacy has not been tested, Vitamin U may serve as an alternative to NAC by those looking for a natural choice to boost their glutathione levels and restore their redox balance on an everyday basis. 

It should be emphasized that any possible overdose of paracetamol/acetaminophen should be treated at a hospital by a doctor and not self-treated with NAC or Vitamin U.